Kidney disease is characterized by the gradual loss of kidney function, leading to a buildup of waste and excess fluids in the body. Kidney failure occurs when the body can no longer remove waste and balance these fluids. While western medicine manages kidney disease through medication and lifestyle changes, these “managed care” techniques do not heal the patient, they simply manage the symptoms until the patient reaches the next stage of disease progression. Following this path of care very often leads to dialysis, kidney transplantation, or premature death. However, recent advances in stem cell therapy have provided an effective alternative for the treatment of kidney disease.
Wharton’s Jelly stem cells (WJSCs) are a type of mesenchymal stem cell found within the gelatinous tissue of the umbilical cord. Their role is to help the baby develop and grow. They have the unique ability to differentiate into various cell types, including kidney cells. This makes them a valuable resource for the treatment of kidney disease.
It is important to note that the use of Wharton’s Jelly stem cells cause no harm to baby or mother. This tissue is donated after successful and healthy birth of the child.
How is stem cell therapy used to treat kidney disease?
One way in which this manner of stem cell therapy is used to treat kidney disease is through the regeneration of damaged kidney tissue. In cases of chronic kidney disease, the kidney tissue is gradually replaced with scar tissue, which impairs its ability to function.
WJSCs are introduced via IV and “home in” to the kidney, where they can differentiate into new kidney cells and promote the regeneration of damaged tissue. This can lead to improved kidney function and a reduction in symptoms.
Another way in which WJSCs can be used to treat kidney disease is through the modulation of the immune system.
In cases of autoimmune kidney disease, the immune system attacks the kidney tissue, leading to inflammation and damage. WJSCs have been shown to modulate the activity of the immune system, reducing inflammation and protecting the kidney tissue from further damage.
WJSCs can also be used to treat acute kidney injury, which is a sudden loss of kidney function. Acute kidney injury can occur as a result of injury, infection, or medication toxicity. WJSCs can be introduced into the bloodstream, where they can migrate to the site of injury and promote the regeneration of damaged kidney tissue. This can lead to a faster recovery and a reduced risk of long-term kidney damage.
What are the advantages o using Wharton’s Jelly derived stem cells to treat kidney failure
One of the advantages of using WJSCs for the treatment of kidney disease is their low immunogenicity. This means that they are not likely to be rejected by the patient’s immune system. In fact, there are no documented cases of rejection.
Several clinical trials have been conducted to investigate the use of WJSCs for the treatment of kidney disease. One study published in Stem Cells Translational Medicine in 2018 investigated the use of WJSCs in patients with chronic kidney disease. The study found that WJSC therapy was safe and well-tolerated and led to a significant improvement in kidney function and a reduction in inflammation.
Another study published in the Journal of Translational Medicine in 2019 investigated the use of WJSCs in patients with acute kidney injury. The study found that WJSC therapy was effective in promoting the regeneration of damaged kidney tissue and reducing inflammation, leading to a faster recovery and a reduced risk of long-term kidney damage.
As you can see, the results of these clinical trials are impressive. WJSC therapy has begun to revolutionize the treatment of kidney disease, providing a safe and effective alternative to traditional therapies such as dialysis and kidney transplantation.
Wharton’s Jelly stem cells are a valuable resource for the treatment of kidney disease. They have the unique ability to differentiate into kidney cells and promote the regeneration of damaged tissue, making them a promising alternative to traditional therapies such as dialysis and kidney transplantation. Stem cell therapy has the potential to improve the lives of millions of people living with kidney disease worldwide.
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