Wharton’s Jelly derived stem cells (WJ-MSCs) are a type of stem cell that can be isolated from the umbilical cord tissue. These cells have been studied for their potential to treat a variety of medical conditions, including stroke.
In stroke treatment, WJ-MSCs are believed to be effective by promoting the regeneration and repair of damaged brain tissue, reducing inflammation and improving blood flow.
They have the ability to differentiate into different cell types, including neurons and glial cells, which are the cells that make up the brain and spinal cord.
Clinical studies have shown that administering WJ-MSCs to stroke patients can lead to improvements in neurological function, motor function, and quality of life.
Patients have shown significant improvements in their ability to walk, speak, and perform other daily activities.
The administration of WJ-MSCs typically involves introducing the cells directly into the bloodstream intravenously This method has been shown to be safe and well-tolerated by patients.
The parts of the brain that are damaged from a stroke depend on the location and extent of the damage. There are two main types of stroke:
- Ischemic, which is caused by a blockage of blood flow to the brain
- Hemorrhagic, which is caused by bleeding in the brain.
How can stem cell therapy help after an Ischemic stroke?
In an ischemic stroke, the blockage of blood flow leads to a lack of oxygen and nutrients to the affected area of the brain, which can result in damage to the brain tissue.
The specific areas of the brain that are affected depend on the location of the blockage, but commonly affected areas include the cerebral cortex, basal ganglia, and cerebellum.
Wharton’s jelly stem cells (WJSCs) have been shown to have numerous therapeutic effects in ischemic stroke. These include:
- Anti-inflammatory effects: WJSCs can suppress inflammation in the brain, which is a major contributor to tissue damage after stroke.
- Neuroprotective effects: WJSCs can protect neurons from damage and death by producing growth factors and other neuroprotective molecules.
- Angiogenic effects: WJSCs can promote the formation of new blood vessels, which can help restore blood flow to the damaged areas of the brain.
- Immunomodulatory effects: WJSCs can modulate the immune response after stroke, reducing the risk of secondary damage.
Studies have demonstrated the efficacy of WJSCs for the treatment of ischemic stroke, with promising results in terms of improved neurological function and tissue repair. Clinical trials are currently underway to further investigate the safety and efficacy of WJSCs in stroke patients.
Hemorrhagic care with stem cell therapy
In a hemorrhagic stroke, bleeding in the brain can cause damage to the surrounding tissue. The location and extent of the bleeding determine which parts of the brain are affected, but commonly affected areas include the basal ganglia, thalamus, and brainstem.
The symptoms of stroke can vary depending on which parts of the brain are affected but can include paralysis or weakness on one side of the body, difficulty speaking or understanding speech, vision problems, and problems with coordination and balance. Treatment for stroke typically involves medications and rehabilitation to help manage symptoms and promote recovery.
There are several ways in which WJSCs can help hemorrhagic stroke victims:
- Anti-inflammatory properties: WJSCs have been shown to have anti-inflammatory properties that can help reduce inflammation in the brain following a hemorrhagic stroke. This can help prevent further damage to brain tissue and promote healing.
- Neuroprotective effects: WJSCs can produce growth factors and other molecules that promote the survival of neurons, which can help protect the brain from further damage and support the regeneration of damaged tissue.
- Angiogenesis: WJSCs can stimulate the formation of new blood vessels in the brain, which can help improve blood flow and oxygen delivery to damaged tissue.
- Immunomodulatory effects: WJSCs can modulate the immune response in the brain, which can help reduce inflammation and promote healing.
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Stem cell therapy utilizing WJSCs in the treatment of stroke patients holds great promise for improving outcomes for patients who have suffered this devastating condition.